The orexin/hypocretin system : physiology and pathophysiology / edited by Seiji Nishino and Takeshi Sakurai.
"Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future tr...
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| Corporate Author: | |
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| Other Authors: | , |
| Format: | Ebook |
| Language: | English |
| Published: |
Towota, N.J. :
Humana Press,
c2005.
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| Series: | Contemporary clinical neuroscience.
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| Subjects: | |
| Online Access: | Springer eBooks |
MARC
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| 245 | 0 | 4 | |a The orexin/hypocretin system : |b physiology and pathophysiology / |c edited by Seiji Nishino and Takeshi Sakurai. |
| 260 | |a Towota, N.J. : |b Humana Press, |c c2005. | ||
| 300 | |a 1 electronic document. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Contemporary clinical neuroscience | |
| 500 | |a Description based on print version record. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | 0 | |t History: -- |t History and Overview of Orexin/Hypocretin Research / |r Michihiro Mieda, Takeshi Sakurai -- |t Overview of the Orexin/Hypocretin Neuronal System: -- |t Orexin and Orexin Receptors / |r Takeshi Sakurai -- |t Orexin Projections and Localization of Orexin Receptors / |r Jacob N. Marcus, Joel K. Elmquist -- |t Neuronal Responses to Hypocretin/Orexin / |r Anthony N. van den Pol, Claudio Acuna-Goycolea -- |t Afferent System of Orexin Neurons / |r Akihiro Yamanaka -- |t Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids: -- |t Hypocretin Measurements in the CSF, and Blood and Brain Tissue / |r Seiji Nishino -- |t Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTPγS Autoradiography / |r René Bernard, Ralph Lydic, Helen A. Baghdoyan -- |t Physiology: -- |t Orexin System and Feeding Behavior / |r Takeshi Sakurai -- |t Orexins and the Autonomic Nervous System / |r Tetsuro Shirasaka, Masamitsu Nakazato -- |t Neuroendocrine Role of the Orexins (Hypocretins) / |r Shahrad Taheri -- |t The Orexin/Hypocretin System and Stress and Emotion / |r Yoichi Ueta, Hiroaki Fujihara -- |t Physiology: -- |t Hypocretin as a Wakefulness Regulatory Peptide / |r Luis de Lecea, J. Gregor Sutcliffe -- |t Hypocretin/Orexin Tonus and Vigilance Control / |r Yasushi Yoshida, Seiji Nishino -- |t Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance / |r Krister S. Eriksson, Helmut L. Haas -- |t Orexin and Hypothalamic Control of Sleep and Waking / |r Rodrigo A. España, Thomas E. Scammell -- |t Hypocretin/Orexin and Motor Function / |r Jerome M. Siegel -- |t Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency: -- |t Overview of Human Narcolepsy / |r Scott Fromherz, Emmanuel Mignot -- |t Canine Models of Narcolepsy / |r Seiji Nishino -- |t Rodent Models of Human Narcolepsy-Cataplexy / |r Michihiro Mieda, Masashi Yanagisawa -- |t Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency: -- |t Hypocretin Deficiency in Human Narcolepsy / |r Patrice Bourgin, Jamie M. Zeitzer, Emmanuel Mignot -- |t Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy / |r Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Tetsuo Shimizu, Seiji Nishino -- |t Hypocretin Measures in Psychiatric Disorders / |r Ronald M. Salomon -- |t Neuroendocrinology of Human Narcolepsy / |r Gert Jan Lammers, Sebastiaan Overeem, Hanno Pijl -- |t Narcolepsy and Autoimmunity / |r Shahrad Taheri, Jose Paterno, Ling Lin, Emmauel Mignot -- |t Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency: -- |t Pharmacology of Hypocretin/Orexin Peptides and Small Molecules / |r Stephen J. Perry, David A. Schwarz, Richard A. Maki -- |t Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides / |r Michihiro Mieda, Jon T. Willie, Takeshi Sakurai -- |t Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy / |r Nobuhiro Fujiki, Seiji Nishino. |
| 520 | |a "Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations.Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation."--Publisher's website. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 588 | |a Automated GMD conversion. | ||
| 650 | 0 | |a Narcolepsy |9 347514 | |
| 650 | 0 | |a Orexins |9 347387 | |
| 700 | 1 | |a Nishino, Seiji. |9 821416 | |
| 700 | 1 | |a Sakurai, Takeshi. |9 302878 | |
| 710 | 2 | |a SpringerLink ebooks - Biomedical and Life Sciences (2005) | |
| 830 | 0 | |a Contemporary clinical neuroscience. |9 1098895 | |
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