Two faces of evil : cancer and neurodegeneration / Thomas Curran, Yves Christen, editors.
"Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processe...
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| Other Authors: | , |
| Format: | Ebook |
| Language: | English |
| Published: |
Heidelberg :
Springer,
c2011.
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| Series: | Research and perspectives in Alzheimer's disease.
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| Subjects: | |
| Online Access: | Springer eBooks |
MARC
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| 245 | 0 | 0 | |a Two faces of evil : |b cancer and neurodegeneration / |c Thomas Curran, Yves Christen, editors. |
| 246 | 3 | |a 2 faces of evil | |
| 260 | |a Heidelberg : |b Springer, |c c2011. | ||
| 300 | |a 1 electronic document. | ||
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| 490 | 1 | |a Research and perspectives in Alzheimer's disease, |x 0945-6066 | |
| 500 | |a Description based on print version record. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | 0 | |t Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer / |r Mariano Barbacid -- |t The Role of Cdk5 as a Cell Cycle Suppressor in Post-mitotic Neurons / |r Karl Herrup -- |t Actin-SRF Signaling in the Developing and Mature Murine Brain / |r Alfred Nordheim, Bernd Knöll -- |t The E3 Ubiquitin Ligase Ube3A Regulates Synaptic Function Through the Ubiquitination of Arc / |r Eric C. Griffith, Paul L. Greer, Michael E. Greenberg -- |t Targeting Children’s Brain Tumors: Development of Hedgehog Pathway Inhibitors for Medulloblastoma / |r Tom Curran -- |t Primary Cilia as Switches in Brain Development and Cancer / |r Young-Goo Han, Arturo Alvarez-Buylla -- |t Nervous System Aging, Degeneration, and the p53 Family / |r Freda D. Miller, David R. Kaplan -- |t p53, a Molecular Bridge Between Alzheimer’s Disease Pathology and Cancers? / |r Frédéric Checler, Julie Dunys, Raphaëlle Pardossi-Piquard, Cristine Alves da Costa -- |t RNA regulation in Neurodegeneration and Cancer / |r Robert B. Darnell -- |t Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain / |r Dengke K. Ma, Junjie U. Guo, Guo-li Ming, Hongjun Song -- |t Intrinsic Brain Signaling Pathways: Targets of Neuron Degeneration / |r Harry T. Orr -- |t The miRNA System: Bifurcation Points of Cancer and Neurodegeneration / |r Kenneth S. Kosik, Pierre Neveu, Sourav Banerjee -- |t Molecular Mechanisms for the Initiation and Maintenance of Long-Term Memory Storage / |r Sathyanarayanan Puthanveettil, Eric Kandel. |
| 520 | |a "Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration representyin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes"--Publisher's website. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 588 | |a Automated GMD conversion. | ||
| 650 | 0 | |a Alzheimer's disease |x Etiology |9 813148 | |
| 650 | 0 | |a Nervous system |x Degeneration |x Pathophysiology. | |
| 650 | 0 | |a Tumors |x Etiology |9 813037 | |
| 650 | 2 | |a Cell Death. |9 358722 | |
| 650 | 2 | |a Cell Proliferation. |9 361917 | |
| 650 | 2 | |a Homeostasis |x physiology |9 361348 | |
| 700 | 1 | |a Christen, Yves. |9 296009 | |
| 700 | 1 | |a Curran, Tom. |9 822770 | |
| 710 | 2 | |a SpringerLink ebooks - Biomedical and Life Sciences (2011) | |
| 830 | 0 | |a Research and perspectives in Alzheimer's disease. |x 0945-6066. |9 1098736 | |
| 856 | 4 | 0 | |u https://ezproxy.aut.ac.nz/login?url=https://link.springer.com/10.1007/978-3-642-16602-0 |z Springer eBooks |x TEMPORARY ERM URL |
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