Structural and functional organization of the synapse / edited by Johannes W. Hell and Michael D. Ehlers.
"The synapse is a fascinating structure for many reasons. Biologically, it is an exquisitely organized subcellular compartment that has a remarkable capacity for fidelity and endurance. Computationally, synapses play a central role in signal transmission and processing that represent evolution’...
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Ebook |
| Language: | English |
| Published: |
New York :
Springer,
c2008.
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| Subjects: | |
| Online Access: | Springer eBooks |
MARC
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| 245 | 0 | 0 | |a Structural and functional organization of the synapse / |c edited by Johannes W. Hell and Michael D. Ehlers. |
| 246 | 3 | |a Structural and functional organisation of the synapse | |
| 264 | 1 | |a New York : |b Springer, |c c2008. | |
| 300 | |a 1 electronic document (xviii, 801 p.: |b ill. (some col.)) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Description based on print version record. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | 0 | |t Diversity in Synapse Structure and Composition / |r Johannes W. Hell, Michael D. Ehlers -- |t The Role of Glutamate Transporters in Synaptic Transmission / |r Dwight E. Bergles, Robert H. Edwards -- |t Structure and Function of Vertebrate and Invertebrate Active Zones / |r Craig C. Garner, Kang Shen -- |t Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function / |r Deniz Atasoy, Ege T. Kavalali -- |t The Molecular Machinery for Synaptic Vesicle Endocytosis / |r Peter S. McPherson, Brigitte Ritter, George J. Augustine -- |t Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes / |r Zu-Hang Sheng, Amy Lee, William A. Catterall -- |t Adhesion Molecules at the Synapse / |r Alaa El-Husseini -- |t Dendritic Organelles for Postsynaptic Trafficking / |r Cyril Hanus, Michael D. Ehlers -- |t Structure and Mechanism of Action of AMPA and Kainate Receptors / |r Mark L. Mayer -- |t Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity / |r José A. Esteban -- |t Structure and Function of the NMDA Receptor / |r Hongjie Yuan, Matthew T. Geballe, Kasper B. Hansen, Stephen F. Traynelis -- |t Molecular Properties and Cell Biology of the NMDA Receptor / |r Robert J. Wenthold, Rana A. Al-Hallaq, Catherine Croft Swanwick, Ronald S. Petralia -- |t Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses / |r Daniel Choquet, Antoine Triller -- |t Scaffold Proteins in the Postsynaptic Density / |r Mary B. Kennedy, Edoardo Marcora, Holly J. Carlisle -- |t Ca2+ Signaling in Dendritic Spines / |r Bernardo L. Sabatini, Karel Svoboda -- |t Postsynaptic Targeting of Protein Kinases and Phosphatases / |r Stefan Strack, Johannes W. Hell -- |t Long-Term Potentiation / |r John E. Lisman, Johannes W. Hell -- |t Homeostatic Synaptic Plasticity / |r Gina Turrigiano -- |t Ubiquitin and Protein Degradation in Synapse Function / |r Thomas D. Helton, Michael D. Ehlers -- |t Signaling from Synapse to Nucleus / |r Carrie L. Heusner, Kelsey C. Martin -- |t Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses / |r I. Lorena Arancibia-Carcamo, Antoine Triller, Josef T. Kittler -- |t Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology / |r John A. Wemmie, Xiang-ming Zha, Michael J. Welsh -- |t Glia as Active Participants in the Development and Function of Synapses / |r Cagla Eroglu, Ben A. Barres, Beth Stevens -- |t Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis / |r James O. McNamara, Yang Z. Huang, Enhui Pan -- |t Stroke – A Synaptic Perspective / |r Robert Meller, Roger P. Simon -- |t Introduction and Pathological Pain / |r Michael W. Salter. |
| 520 | |a "The synapse is a fascinating structure for many reasons. Biologically, it is an exquisitely organized subcellular compartment that has a remarkable capacity for fidelity and endurance. Computationally, synapses play a central role in signal transmission and processing that represent evolution’s solution to learning and memory. Nervous systems, including our own brains, possess an extraordinary capacity for adaptation and memory because the synapse, not the neuron, constitutes the basic unit for information storage. Because the molecular complexities underlying signal processing and information storage must occur within the tiny space of the synapse, the precise molecular organization of proteins, lipids, and membranes at the synapse is paramount. Given the central role of the synapse in neuronal communication, it comes as no surprise that dysregulation of the synapse accounts for many, if not most, neurological and psychiatric disorders. Clinically, the synapse thus constitutes a prime target for treatments of these diseases. It is for these reasons that we have chosen to focus our work on deciphering the structural and functional organization of the synapse. We have assembled leaders in the field of synapse biology to describe and distill the wonders and mysteries of the synapse. This book provides a fundamental description of the synapse developed over many decades by numerous investigators, paired with recent insight into new aspects of synapse structure and function that is still in flux and at the cutting edge of research."--Publisher's website. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 588 | |a Automated GMD conversion. | ||
| 588 | |a Description based on print version record. | ||
| 650 | 0 | |a Synapses. |9 336650 | |
| 700 | 1 | |a Ehlers, Michael D. |9 825096 | |
| 700 | 1 | |a Hell, Johannes W. |9 825099 | |
| 776 | 0 | 8 | |i Print version: |t Structural and functional organization of the synapse. |d New York : Springer, c2008 |z 9780387772318 |z 0387772316 |w (OCoLC)191243193 |
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