Drug design : methodology, concepts, and mode-of-action / by Gerhard Klebe.
"Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple app...
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| Main Author: | |
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| Format: | Ebook |
| Language: | English German |
| Published: |
Berlin ; London :
Springer,
2012.
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| Subjects: | |
| Online Access: | Springer eBooks |
Table of Contents:
- Part I Fundamentals in Drug Research:
- Drug Research: Yesterday, Today, and Tomorrow
- In the Beginning, There Was Serendipity
- Classical Drug Research
- Protein–Ligand Interactions as the Basis for Drug Action
- Optical Activity and Biological Effect
- Part II The Search for the Lead Structure:
- The Classical Search for Lead Structures
- Screening Technologies for Lead Structure Discovery
- Optimization of Lead Structures
- Designing Prodrugs
- Peptidomimetics
- Part III Experimental and Theoretical Methods:
- Combinatorics: Chemistry with Big Numbers
- Gene Technology in Drug Research
- Experimental Methods of Structure Determination
- Three-Dimensional Structure of Biomolecules
- Molecular Modeling
- Conformational Analysis
- Pharmacophore Hypotheses and Molecular Comparisons
- Quantitative Structure–Activity Relationships
- From In Vitro to In Vivo: Optimization of ADME and Toxicology Properties
- Protein Modeling and Structure-Based Drug Design
- A Case Study: Structure-Based Inhibitor Design for tRNA-Guanine Transglycosylase
- Part V Drugs and Drug Action: Successes of Structure-Based Design:
- How Drugs Act: Concepts for Therapy
- Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
- Aspartic Protease Inhibitors
- Inhibitors of Hydrolyzing Metalloenzymes
- Transferase Inhibitors
- Oxidoreductase Inhibitors
- Agonists and Antagonists of Nuclear Receptors
- Agonists and Antagonists of Membrane-Bound Receptors
- Ligands for Channels, Pores, and Transporters
- Ligands for Surface Receptors
- Biologicals: Peptides, Proteins, Nucleotides, and Macrolides as Drugs.