Academic Journal
Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV.
| Taitara: | Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV. |
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| Ngā kaituhi: | Ngare, Isaac1,2 (AUTHOR) ngareisaac@yahoo.com, Tan, Toong Seng1 (AUTHOR) tstan@mgh.harvard.edu, Toyoda, Mako1 (AUTHOR) makotoyo@kumamoto-u.ac.jp, Kuwata, Takeo1 (AUTHOR) tkuwata@kumamoto-u.ac.jp, Takahama, Soichiro3 (AUTHOR) takahama.soichiro.bt@mail.hosp.go.jp, Nakashima, Eriko3 (AUTHOR) nakashima.eriko.rj@mail.hosp.go.jp, Yamasaki, Naoya4 (AUTHOR) naoya64@hiroshima-u.ac.jp, Motozono, Chihiro1 (AUTHOR) motozono@kumamoto-u.ac.jp, Fujii, Teruhisa4 (AUTHOR) teruchan@hiroshima-u.ac.jp, Minami, Rumi3 (AUTHOR) minami.rumi.ad@mail.hosp.go.jp, Barabona, Godfrey1 (AUTHOR) barabona@kumamoto-u.ac.jp, Ueno, Takamasa1,2,5 (AUTHOR) uenotaka@kumamoto-u.ac.jp |
| Puna: | Viruses (1999-4915). Apr2024, Vol. 16 Issue 4, p555. 11p. |
| Whakarāpopotonga: | People living with HIV (PLWH) could be at risk of blunted immune responses to COVID-19 vaccination. We investigated factors associated with neutralizing antibody (NAb) responses against SARS-CoV-2 and variants of concern (VOCs), following two-dose and third booster monovalent COVID-19 mRNA vaccination in Japanese PLWH. NAb titers were assessed in polyclonal IgG fractions by lentiviral-based pseudovirus assays. Overall, NAb titers against Wuhan, following two-dose vaccination, were assessed in 82 PLWH on treatment, whereby 17/82 (20.73%) were classified as low-NAb participants. Within the low-NAb participants, the third booster vaccination enhanced NAb titers against Wuhan and VOCs, albeit to a significantly lower magnitude than the rest. In the multivariate analysis, NAb titers against Wuhan after two-dose vaccination correlated with age and days since vaccination, but not with CD4+ count, CD4+/CD8+ ratio, and plasma high-sensitivity C-Reactive protein (hsCRP). Interestingly, an extended analysis within age subgroups revealed NAb titers to correlate positively with the CD4+ count and negatively with plasma hsCRP in younger, but not older, participants. In conclusion, a third booster vaccination substantially enhances NAb titers, but the benefit may be suboptimal in subpopulations of PLWH exhibiting low titers at baseline. Considering clinical and immune parameters could provide a nuanced understanding of factors associated with vaccine responses in PLWH. [ABSTRACT FROM AUTHOR] |
| Ngā kupu marau: | *COVID-19 vaccines, *JAPANESE people, *HIV-positive persons, *ANTIBODY formation, *BOOSTER vaccines |
| Ngā kupu matawhenua: | WUHAN (China) |
| ISSN: | 19994915 |
| DOI: | 10.3390/v16040555 |
| Pātengi raraunga: | Academic Search Index |
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