Academic Journal
Disrupted frontostriatal connectivity in primary insomnia: a DTI study.
| Title: | Disrupted frontostriatal connectivity in primary insomnia: a DTI study. |
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| Authors: | Chen L; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Shao Z; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Xu Y; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Wang S; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Zhang M; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Liu S; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Wen X; School of Life Science and Technology, Xidian University, Xi'an, 710071, China.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China., Liu B; Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China., Xia X; Xi'an Aerosemi Technology Co., LTD, Xi'an, China., Yuan K; School of Life Science and Technology, Xidian University, Xi'an, 710071, China. kyuan@xidian.edu.cn.; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, 710071, China. kyuan@xidian.edu.cn.; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, 014010, China. kyuan@xidian.edu.cn.; School of Life Science and Technology, Xidian University, 266 Xinglong Section of Xifeng Road, Xi'an, Shaanxi, 710126, People's Republic of China. kyuan@xidian.edu.cn., Yu D; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, 014010, China. fmydh@imust.edu.cn. |
| Source: | Brain imaging and behavior [Brain Imaging Behav] 2021 Oct; Vol. 15 (5), pp. 2524-2531. Date of Electronic Publication: 2021 Mar 02. |
| Abstract: | Dysfunction of the sleep-wake transition is considered to be associated with the pathology of patients with primary insomnia (PI). Previous animal study had reported that brain circuits between the striatum and cortex can regulate sleep-wake transitions. So far, few studies have systematically explored the structural connectivity of the striatum-centered circuits and their potential roles in patients with PI. In this study, we chosen the striatum as the seed and 10 priori target regions as masks to assess the structural connectivity by using seed-based classification with a diffusion tensor imaging (DTI) probabilistic tractography method. Track strengths of the striatum-centered circuits were compared between 22 patients with PI (41.27 ± 9.21 years) and 30 healthy controls (HC) (35.2 ± 8.14 years). Pittsburgh Sleep Quality Index (PSQI) was used to measure the sleep quality in all participants. Lower track strengths (left striatum- anterior cingulate cortex (ACC), left striatum- dorsal anterior cingulate cortex (dACC), left striatum-Hippocampus, and right striatum-Hippocampus) were observed in patients with PI compared to HC. Additionally, the lower track strengths of brain circuits mentioned above were negatively correlated with PSQI. Taken together, our findings revealed the lower tract strength of frontostriatal circuits in patients with PI and HC, which provided the implications of the system-level structural connections of frontostriatal circuits in the pathology of PI. We suggested that the track strengths of the frontostriatal circuits calculated from DTI can be the potential neuroimaging biomarkers of the sleep quality in patients with PI. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.) |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Secaucus, NJ : Springer |
| MeSH Terms: | Diffusion Tensor Imaging* , Sleep Initiation and Maintenance Disorders*/diagnostic imaging, Cerebral Cortex ; Gyrus Cinguli ; Humans ; Magnetic Resonance Imaging |
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| Grant Information: | 81871426,81871430 National Natural Science Foundation of China; 2019JQ07 Natural Science Foundation of Inner Mongolia |
| Contributed Indexing: | Keywords: DTI probabilistic tractography; Primary insomnia; Striatum‐centered circuits; Structural connectivity |
| Entry Date(s): | Date Created: 20210302 Date Completed: 20211012 Latest Revision: 20211012 |
| Update Code: | 20240513 |
| DOI: | 10.1007/s11682-021-00454-3 |
| PMID: | 33651331 |
| ISSN: | 1931-7565 |
| DOI: | 10.1007/s11682-021-00454-3 |
| Database: | MEDLINE |