Academic Journal
The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review.
| Title: | The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review. |
|---|---|
| Authors: | Ansarin A; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Pashmineh Research Complex, Daneshgah Street, P.O. Box: 5448151429, Tabriz, Iran., Mahdavi AM; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Pashmineh Research Complex, Daneshgah Street, P.O. Box: 5448151429, Tabriz, Iran.; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Javadivala Z; Department of Health Education & Promotion, Tabriz University of Medical Sciences, Tabriz, Iran., Shanehbandi D; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Zarredar H; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Pashmineh Research Complex, Daneshgah Street, P.O. Box: 5448151429, Tabriz, Iran., Ansarin K; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Pashmineh Research Complex, Daneshgah Street, P.O. Box: 5448151429, Tabriz, Iran. ansarink@tbzmed.ac.ir. |
| Source: | Molecular biology reports [Mol Biol Rep] 2023 Dec; Vol. 50 (12), pp. 10427-10443. Date of Electronic Publication: 2023 Oct 24. |
| Abstract: | Background: Today, modern lifestyles and disrupted sleep patterns cause circadian clock rhythm impairments that are associated with altered leptin levels, which subsequently affect a wide range of physiological processes and have significant health burdens on societies. Nevertheless, there has been no systematic review of circadian clock genes and proteins, leptin, and related signaling pathways. Methods: Accordingly, we systematically reviewed circadian clock proteins, leptin, and molecular mechanisms between them by searching Pubmed, Scopus, ProQuest, Web of Sciences, and Google Scholar until September 2022. After considering the inclusion and exclusion criteria, 20 animal studies were selected. The risk of bias was assessed in each study. Results: The results clarified the reciprocal interconnected relationship between circadian clock genes and leptin. Circadian clock genes regulate leptin expression and signaling via different mechanisms, such as CLOCK-BMAL1 heterodimers, which increase the expression of PPARs. PPARs induce the expression of C/EBPα, a key factor in upregulating leptin expression. CLOCK-BMAL1 also induces the expression of Per1 and Rev-erb genes. PER1 activates mTORC1 and mTORC1 enhances the expression of C/EBPα. In addition, REV-ERBs activate the leptin signaling pathway. Also, leptin controls the expression of circadian clock genes by triggering the AMPK and ERK/MAPK signaling pathways, which regulate the activity of PPARs. Moreover, the roles of these molecular mechanisms are elucidated in different physiological processes and organs. Conclusions: Crosstalk between circadian clock genes and leptin and their affecting elements should be considered in the selection of new therapeutic targets for related disorders, especially obesity and metabolic impairments. (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.) |
| Publication Type: | Systematic Review; Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Dordrecht, Boston, Reidel. |
| MeSH Terms: | Circadian Clocks*/genetics , Circadian Rhythm Signaling Peptides and Proteins*, Animals ; ARNTL Transcription Factors ; Circadian Rhythm/genetics ; Leptin/genetics ; Mechanistic Target of Rapamycin Complex 1 ; Nuclear Receptor Subfamily 1, Group D, Member 1/genetics ; Nuclear Receptor Subfamily 1, Group D, Member 1/metabolism ; Peroxisome Proliferator-Activated Receptors ; Humans |
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| Contributed Indexing: | Keywords: BMAL1; Circadian rhythm; Clock genes; Leptin; Metabolism; REV-ERBα |
| Substance Nomenclature: | 0 (ARNTL Transcription Factors) 0 (Circadian Rhythm Signaling Peptides and Proteins) 0 (Leptin) EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1) 0 (Nuclear Receptor Subfamily 1, Group D, Member 1) 0 (Peroxisome Proliferator-Activated Receptors) 0 (LEP protein, human) |
| Entry Date(s): | Date Created: 20231024 Date Completed: 20231130 Latest Revision: 20231220 |
| Update Code: | 20231220 |
| DOI: | 10.1007/s11033-023-08887-3 |
| PMID: | 37874505 |
| ISSN: | 1573-4978 |
| DOI: | 10.1007/s11033-023-08887-3 |
| Database: | MEDLINE |