Academic Journal
View in EDS

Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling.

Bibliographic Details
Title: Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling.
Authors: Sun X; School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China., Zhou X; School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China., He W; Department of Nephrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People's Republic of China., Sun W; Department of Nephrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People's Republic of China., Xu Z; School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2023 Dec 24; Vol. 17, pp. 3803-3831. Date of Electronic Publication: 2023 Dec 24 (Print Publication: 2023).
Abstract: Dysregulation of the gut microbial ecosystem (GME) (eg, alterations in the gut microbiota, gut-derived metabolites, and gut barrier) may contribute to the onset and progression of extra-intestinal diseases. Previous studies have found that Traditional Chinese Medicine herbs (TCMs) play an important role in manipulating the GME, but a prominent obstacle in current TCM research is the causal relationship between GME and disease amelioration. Encouragingly, co-housing and fecal microbiota transplantation (FMT) provide evidence-based support for TCMs to treat extra-intestinal diseases by targeting GME. In this review, we documented the principles, operational procedures, applications and limitations of the key technologies (ie, co-housing and FMT); furthermore, we provided evidence that TCM works through the GME, especially the gut microbiota (eg, SCFA- and BSH-producing bacteria), the gut-derived metabolites (eg, IS, pCS, and SCFAs), and intestinal barrier to alleviate extra-intestinal diseases. This will be beneficial in constructing microecological pathways for TCM treatment of extra-intestinal diseases in the future.
Competing Interests: All authors declare no conflicts of interest.
(© 2023 Sun et al.)
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Imprint Name(s): Original Publication: [Auckland, N.Z.] : Dove Press Limited
MeSH Terms: Gastrointestinal Microbiome*/physiology , Intestinal Diseases*/drug therapy, Humans ; Fecal Microbiota Transplantation/methods ; Housing
References: J Am Assoc Lab Anim Sci. 2011 Sep;50(5):600-13. (PMID: 22330705)
Sci Rep. 2017 Oct 19;7(1):13537. (PMID: 29051531)
Int Immunopharmacol. 2023 Jul;120:110278. (PMID: 37192552)
Infection. 2012 Dec;40(6):643-8. (PMID: 22847629)
Front Cell Infect Microbiol. 2022 Mar 30;12:855075. (PMID: 35433500)
Int J Mol Sci. 2020 Aug 26;21(17):. (PMID: 32858886)
Pharmacol Res. 2023 Mar;189:106687. (PMID: 36746362)
Cell Host Microbe. 2020 Jun 10;27(6):899-908.e5. (PMID: 32348782)
JAMA. 2017 Nov 28;318(20):1985-1993. (PMID: 29183074)
Mol Biol Rep. 2023 Feb;50(2):1663-1675. (PMID: 36399245)
Gut Microbes. 2021 Jan-Dec;13(1):1-20. (PMID: 34125646)
Front Neurosci. 2022 Dec 15;16:956620. (PMID: 36590298)
Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1227-H1233. (PMID: 32986965)
Inflamm Bowel Dis. 2015 Jul;21(7):1600-6. (PMID: 26070003)
Front Immunol. 2022 Aug 12;13:930872. (PMID: 36032108)
Gut Microbes. 2021 Jan-Dec;13(1):1941711. (PMID: 34328058)
Hepatol Commun. 2022 Aug;6(8):2079-2089. (PMID: 35384391)
J Neuroinflammation. 2022 Oct 4;19(1):245. (PMID: 36195899)
Gut. 2017 Apr;66(4):569-580. (PMID: 28087657)
Mol Neurobiol. 2022 Nov;59(11):6684-6700. (PMID: 35986843)
J Autoimmun. 2022 Jun;130:102844. (PMID: 35690527)
Front Cell Infect Microbiol. 2022 Apr 28;12:863779. (PMID: 35573786)
BMJ Open Diabetes Res Care. 2023 May;11(3):. (PMID: 37253485)
Free Radic Biol Med. 2021 Feb 1;163:180-189. (PMID: 33352218)
Nephrol Dial Transplant. 2014 Jan;29(1):56-64. (PMID: 24166466)
Front Med (Lausanne). 2022 Mar 03;9:829349. (PMID: 35308555)
Gastroenterology. 2021 Jan;160(1):145-157.e8. (PMID: 32681922)
Front Pharmacol. 2022 Jun 22;13:858881. (PMID: 35814258)
Gut. 2020 Mar;69(3):513-522. (PMID: 31900289)
Biochem Pharmacol. 2023 Jul;213:115599. (PMID: 37196685)
Int J Mol Sci. 2023 Jan 12;24(2):. (PMID: 36674986)
Cell. 2019 May 30;177(6):1600-1618.e17. (PMID: 31150625)
Mol Nutr Food Res. 2021 Jan;65(1):e2000202. (PMID: 32558187)
Surgery. 1958 Nov;44(5):854-9. (PMID: 13592638)
Sci Rep. 2022 Nov 15;12(1):19621. (PMID: 36380056)
J Clin Transl Hepatol. 2023 Apr 28;11(2):452-458. (PMID: 36643028)
Microbiol Spectr. 2023 Feb 14;11(1):e0215921. (PMID: 36472435)
Front Cell Infect Microbiol. 2023 Apr 11;13:1103189. (PMID: 37113132)
Gut Pathog. 2021 Aug 14;13(1):52. (PMID: 34391464)
Diabetes Care. 2022 Mar 1;45(3):555-563. (PMID: 35045174)
Front Cell Infect Microbiol. 2022 Jul 04;12:759306. (PMID: 35860380)
JCI Insight. 2020 Apr 9;5(7):. (PMID: 32271169)
Mol Neurodegener. 2022 Jun 17;17(1):43. (PMID: 35715821)
Am J Gastroenterol. 2012 Nov;107(11):1755; author reply p.1755-6. (PMID: 23160295)
Front Cell Infect Microbiol. 2022 Nov 08;12:997018. (PMID: 36425787)
Microbiol Spectr. 2022 Jun 29;10(3):e0075922. (PMID: 35481834)
J Law Biosci. 2015 Jul 06;2(2):396-415. (PMID: 27774199)
Protein Cell. 2020 Apr;11(4):251-266. (PMID: 31919742)
Adv Ther. 2018 Nov;35(11):1935-1944. (PMID: 30328062)
Curr Opin Pharmacol. 2019 Dec;49:24-28. (PMID: 31085417)
Blood. 2023 Apr 6;141(14):1691-1707. (PMID: 36638348)
Front Immunol. 2023 Apr 25;14:1139913. (PMID: 37180163)
Gut. 2020 May;69(5):859-867. (PMID: 31852769)
J Formos Med Assoc. 2019 Mar;118 Suppl 1:S23-S31. (PMID: 30181015)
Cell. 2015 Dec 17;163(7):1585-95. (PMID: 26687352)
Front Pharmacol. 2021 Dec 13;12:780924. (PMID: 34966280)
Front Microbiol. 2022 Nov 30;13:1037257. (PMID: 36532422)
Kidney Int. 2012 Apr;81(7):640-50. (PMID: 22237753)
Clin Sci (Lond). 2019 Sep 10;133(17):1857-1870. (PMID: 31467135)
Pharmacol Res. 2019 Jan;139:412-421. (PMID: 30508676)
Biol Pharm Bull. 2020 May 1;43(5):788-800. (PMID: 32132347)
Front Microbiol. 2022 Oct 19;13:1017147. (PMID: 36338055)
Atherosclerosis. 2023 Apr;371:32-40. (PMID: 36990029)
Curr Res Food Sci. 2022 Dec 28;6:100426. (PMID: 36618099)
Comp Med. 2014 Oct;64(5):369-76. (PMID: 25402177)
Clin Infect Dis. 2018 Mar 19;66(7):e1-e48. (PMID: 29462280)
Transl Psychiatry. 2023 Jan 21;13(1):17. (PMID: 36670104)
Gut Microbes. 2022 Jan-Dec;14(1):2038856. (PMID: 35230889)
World J Gastroenterol. 2019 Jul 21;25(27):3590-3606. (PMID: 31367159)
Front Cell Infect Microbiol. 2022 May 20;12:837205. (PMID: 35669118)
Phytomedicine. 2022 Apr;98:153937. (PMID: 35104764)
Int J Biol Macromol. 2023 Sep 1;248:125725. (PMID: 37419267)
Front Immunol. 2018 Feb 26;9:363. (PMID: 29535731)
Ecotoxicol Environ Saf. 2022 Sep 1;242:113925. (PMID: 35917710)
J Orthop Translat. 2022 Sep 26;37:46-60. (PMID: 36196151)
PLoS One. 2012;7(3):e34026. (PMID: 22479508)
Front Pharmacol. 2020 May 04;11:549. (PMID: 32431609)
Circulation. 2019 Mar 12;139(11):1407-1421. (PMID: 30586752)
Nat Commun. 2020 Apr 24;11(1):1995. (PMID: 32332732)
Front Med (Lausanne). 2022 Dec 08;9:1060581. (PMID: 36569149)
Protein Cell. 2021 May;12(5):394-410. (PMID: 32929698)
Front Pharmacol. 2022 Nov 18;13:1052110. (PMID: 36467061)
Am J Gastroenterol. 2012 Jul;107(7):1079-87. (PMID: 22450732)
Front Cell Infect Microbiol. 2022 Jun 29;12:854849. (PMID: 35846749)
Pharmacol Res. 2019 Dec;150:104489. (PMID: 31689519)
Clin Microbiol Infect. 2017 Dec;23(12):924-930. (PMID: 28529025)
Ageing Res Rev. 2022 Nov;81:101706. (PMID: 35932976)
Biomedicines. 2023 Jul 24;11(7):. (PMID: 37509715)
World J Gastroenterol. 2013 Feb 7;19(5):616-30. (PMID: 23431068)
Microbiome. 2019 Aug 22;7(1):116. (PMID: 31439031)
N Engl J Med. 2013 Jan 31;368(5):407-15. (PMID: 23323867)
Gut Microbes. 2020 Nov 1;11(6):1774-1789. (PMID: 32529941)
Front Immunol. 2021 Apr 21;12:673423. (PMID: 33968083)
FASEB J. 2019 Aug;33(8):9308-9322. (PMID: 31145641)
Cell Rep. 2022 Dec 27;41(13):111890. (PMID: 36577369)
Nat Rev Gastroenterol Hepatol. 2017 Jan;14(1):9-21. (PMID: 27848962)
J Ethnopharmacol. 2022 Aug 10;294:115333. (PMID: 35500802)
Nat Rev Cardiol. 2017 Dec;14(12):699-700. (PMID: 29099096)
Front Cell Infect Microbiol. 2022 Jun 16;12:856633. (PMID: 35782123)
Cell Metab. 2018 Feb 6;27(2):378-392.e5. (PMID: 29414686)
Redox Biol. 2021 Oct;46:102115. (PMID: 34474396)
Genomics Proteomics Bioinformatics. 2021 Oct;19(5):679-688. (PMID: 34560321)
Naunyn Schmiedebergs Arch Pharmacol. 2023 Jan;396(1):83-97. (PMID: 36125532)
Nat Rev Immunol. 2023 Jan;23(1):9-23. (PMID: 35534624)
Gastroenterol Clin North Am. 2017 Mar;46(1):171-185. (PMID: 28164849)
Biomed Pharmacother. 2021 Jan;133:110857. (PMID: 33197760)
Gut Microbes. 2022 Jan-Dec;14(1):2112882. (PMID: 35982604)
Front Cell Infect Microbiol. 2022 Feb 28;12:827395. (PMID: 35295757)
Anal Chem. 2016 May 3;88(9):4661-8. (PMID: 27065191)
Front Cell Infect Microbiol. 2022 Jul 28;12:900652. (PMID: 35967846)
Lab Anim. 2012 Jul;46(3):231-6. (PMID: 22723645)
Biomed Pharmacother. 2021 Sep;141:111896. (PMID: 34246956)
Pharmacol Res. 2020 Sep;159:104954. (PMID: 32492490)
J Affect Disord. 2022 Nov 1;316:187-193. (PMID: 35961601)
Nature. 2011 Apr 7;472(7341):57-63. (PMID: 21475195)
Clin Exp Hypertens. 2023 Dec 31;45(1):2195135. (PMID: 36994745)
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2960-E2969. (PMID: 29531080)
Front Physiol. 2019 Jul 23;10:918. (PMID: 31396097)
Lab Anim (NY). 2012 May;41(5):129-34. (PMID: 22517091)
Physiol Behav. 2016 Sep 1;163:167-176. (PMID: 27211331)
Nature. 2017 Dec 14;552(7684):244-247. (PMID: 29211710)
Gut Microbes. 2020 Sep 2;11(5):1450-1474. (PMID: 32515683)
Toxins (Basel). 2020 Apr 11;12(4):. (PMID: 32290429)
Cell Host Microbe. 2016 Dec 14;20(6):691-692. (PMID: 27978427)
Gut. 2020 Mar;69(3):502-512. (PMID: 31147381)
Kidney Int. 2013 Apr;83(4):582-92. (PMID: 23325087)
Ital J Pediatr. 2019 Aug 28;45(1):116. (PMID: 31462301)
Front Immunol. 2021 Dec 03;12:799788. (PMID: 34925385)
Brain Behav Immun. 2021 Jul;95:401-412. (PMID: 33895287)
Proc Nutr Soc. 2021 Feb;80(1):37-49. (PMID: 32238208)
Clin J Oncol Nurs. 2015 Feb;19(1):111-4. (PMID: 25689657)
Gastroenterology. 2022 Oct;163(4):982-994.e14. (PMID: 35709830)
Kidney Int. 2023 Sep;104(3):470-491. (PMID: 37011727)
Curr Opin Pharmacol. 2019 Dec;49:29-33. (PMID: 31103793)
Pharmacol Res. 2018 Mar;129:329-336. (PMID: 29233677)
EBioMedicine. 2023 Apr;90:104527. (PMID: 36963238)
Lancet Gastroenterol Hepatol. 2023 Jan;8(1):66-80. (PMID: 36334596)
PLoS One. 2016 Jun 13;11(6):e0157259. (PMID: 27295210)
Int Urol Nephrol. 2019 Feb;51(2):293-302. (PMID: 30604232)
Biomed Pharmacother. 2022 Nov;155:113810. (PMID: 36271581)
J Neuroinflammation. 2023 May 19;20(1):117. (PMID: 37208728)
Clin Endosc. 2016 May;49(3):257-65. (PMID: 26956193)
Contributed Indexing: Keywords: TCM herb; co-housing; extra-intestinal disease; fecal microbiota transplantation; gut microbial ecosystem
Entry Date(s): Date Created: 20231229 Date Completed: 20240102 Latest Revision: 20240102
Update Code: 20240103
PubMed Central ID: PMC10753978
DOI: 10.2147/DDDT.S443462
PMID: 38155743
ISSN: 1177-8881
DOI: 10.2147/DDDT.S443462
Database: MEDLINE
Availability
Full text via Taylor & Francis
Check for other full text
Open access version