Academic Journal
Calcium restriction for 28 days markedly and negatively influences bone mineral density of the femur and lumbar vertebrae regardless of the high-fat diet ingestion in young adult male rats.
| Title: | Calcium restriction for 28 days markedly and negatively influences bone mineral density of the femur and lumbar vertebrae regardless of the high-fat diet ingestion in young adult male rats. |
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| Authors: | Oku Y; Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan., Noda S; Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan., Ishii S; Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan., Yamada A; Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan., Nakaoka K; Department of Food and Nutrition, Faculty of Human Life, Jumonji University, Saitama, Japan., Goseki-Sone M; Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan. Electronic address: goseki@fc.jwu.ac.jp. |
| Source: | Nutrition research (New York, N.Y.) [Nutr Res] 2024 Apr; Vol. 124, pp. 55-64. Date of Electronic Publication: 2024 Jan 30. |
| Abstract: | Calcium (Ca) is necessary for bone calcification, and Ca deficiency leads to decreased bone mineral density (BMD). Epidemiological studies have reported a correlation between Ca intake and BMD. Although the influences of Ca deficiency on BMD have been reported, the effects of Ca restriction on bone during high-fat diet ingestion remain unclear. Therefore, we hypothesized that high-fat diet ingestion would potentiate the negative effects of Ca restriction on bone. Sprague-Dawley strain male rats (aged 11 weeks) were divided into 4 groups: basic control diet (Cont.) (11% lipid energy rate, 0.5% calcium), basic control diet with Ca restriction (CaR) (11% lipid energy rate, 0.02% calcium), high-fat diet (HF) (40% lipid energy rate, 0.5% calcium), and high-fat diet with Ca restriction (HFCaR) (40% lipid energy rate, 0.02% calcium). At 28 days after starting the experimental diets, body weights were higher in the high-fat diet groups (HF and HFCaR) than in the standard-fat diet groups (Cont. and CaR) on 2-way analysis of variance. The apparent Ca absorption rate in the Ca-restricted groups (CaR and HFCaR) was higher than in the Ca-sufficient groups (Cont. and HF). BMD and bone strength parameters of the femur and lumbar vertebrae in the Ca-restricted groups were markedly lower than in the Ca-sufficient groups, whereas there were no significant differences between the standard-fat diet and HF diet groups. These results suggest that 28 days of Ca restriction increases the risk of bone fracture and osteoporosis. Competing Interests: Declaration of competing interest There are no conflicts of interest to disclose. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2004- > : Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon Press, c1981- |
| MeSH Terms: | Bone Density* , Femur*/metabolism , Diet, High-Fat*/adverse effects , Lumbar Vertebrae* , Rats, Sprague-Dawley* , Calcium, Dietary*/administration & dosage, Animals ; Male ; Rats ; Calcium/metabolism ; Calcium/blood ; Body Weight ; Osteoporosis/etiology ; Dietary Fats/administration & dosage |
| Contributed Indexing: | Keywords: Bone mineral density; Calcium absorption; Calcium restriction; High-fat diet; Rats |
| Substance Nomenclature: | 0 (Calcium, Dietary) SY7Q814VUP (Calcium) 0 (Dietary Fats) |
| Entry Date(s): | Date Created: 20240222 Date Completed: 20240501 Latest Revision: 20240501 |
| Update Code: | 20240502 |
| DOI: | 10.1016/j.nutres.2024.01.015 |
| PMID: | 38387406 |
| ISSN: | 1879-0739 |
| DOI: | 10.1016/j.nutres.2024.01.015 |
| Database: | MEDLINE |
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