Academic Journal
Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy.
| Title: | Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy. |
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| Authors: | Mahajan D; Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India., Kumar T; Department of Veterinary Clinical Complex, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125001, India., Rath PK; Department of Veterinary Pathology, College of Veterinary Science and AH, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha 751003, India., Sahoo AK; Department of Veterinary Pathology, College of Veterinary Science and AH, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha 751003, India.; Department of Veterinary Surgery and Radiology, College of Veterinary Science and AH, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha 751003, India., Mishra BP; Department of Veterinary Pathology, College of Veterinary Science and AH, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha 751003, India.; Department of Livestock Products Technology, College of Veterinary Science and AH, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha 751003, India., Kumar S; Proteomics and Structural Biology Laboratory, Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana 132001, India., Nayak NR; Department of Obstetrics and Gynecology, UMKC School of Medicine, Kansas City, MO 64108, USA., Jena MK; Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India. |
| Source: | Archivum immunologiae et therapiae experimentalis [Arch Immunol Ther Exp (Warsz)] 2024 May 23; Vol. 72 (1). Date of Electronic Publication: 2024 May 23 (Print Publication: 2024). |
| Abstract: | Pregnancy is a remarkable event where the semi-allogeneic fetus develops in the mother's uterus, despite genetic and immunological differences. The antigen handling and processing at the maternal-fetal interface during pregnancy appear to be crucial for the adaptation of the maternal immune system and for tolerance to the developing fetus and placenta. Maternal antigen-presenting cells (APCs), such as macrophages (Mφs) and dendritic cells (DCs), are present at the maternal-fetal interface throughout pregnancy and are believed to play a crucial role in this process. Despite numerous studies focusing on the significance of Mφs, there is limited knowledge regarding the contribution of DCs in fetomaternal tolerance during pregnancy, making it a relatively new and growing field of research. This review focuses on how the behavior of DCs at the maternal-fetal interface adapts to pregnancy's unique demands. Moreover, it discusses how DCs interact with other cells in the decidual leukocyte network to regulate uterine and placental homeostasis and the local maternal immune responses to the fetus. The review particularly examines the different cell lineages of DCs with specific surface markers, which have not been critically reviewed in previous publications. Additionally, it emphasizes the impact that even minor disruptions in DC functions can have on pregnancy-related complications and proposes further research into the potential therapeutic benefits of targeting DCs to manage these complications. (© 2024 Deviyani Mahajan et al., published by Sciendo.) |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Sciendo Country of Publication: Poland NLM ID: 0114365 Publication Model: eCollection Cited Medium: Internet ISSN: 1661-4917 (Electronic) Linking ISSN: 0004069X NLM ISO Abbreviation: Arch Immunol Ther Exp (Warsz) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : Warsaw, Poland : Sciendo Original Publication: Warszawa, Panstwowy Zakład Wydawn. Lekarskich. |
| MeSH Terms: | Dendritic Cells*/immunology , Immune Tolerance* , Maternal-Fetal Exchange*/immunology , Placenta*/immunology, Humans ; Pregnancy ; Female ; Fetus/immunology ; Animals ; Macrophages/immunology ; Pregnancy Complications/immunology |
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| Grant Information: | R01 HD088549 United States HD NICHD NIH HHS |
| Contributed Indexing: | Keywords: Dendritic cells; Endometrium; Hematopoietic stem cells; Placenta; Pregnancy |
| Entry Date(s): | Date Created: 20240523 Date Completed: 20240523 Latest Revision: 20240625 |
| Update Code: | 20240625 |
| DOI: | 10.2478/aite-2024-0010 |
| PMID: | 38782369 |
| ISSN: | 1661-4917 |
| DOI: | 10.2478/aite-2024-0010 |
| Database: | MEDLINE |