Academic Journal
Morphometric Assessment of Intratumoral Stroma Changes in Gastric Carcinoma.
| Title: | Morphometric Assessment of Intratumoral Stroma Changes in Gastric Carcinoma. |
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| Authors: | Pleșea, Iancu-Emil, Glavici, Aurelia, Uscatu, Constantin Daniel, Șerbănescu, Mircea Sebastian, Pleșea, Răzvan Mihail, Grigorean, Valentin Titus, Eugen Strâmbu, Victor Dan, Păun, Ion |
| Source: | Journal of Pathology Informatics; 11/11/2019, Vol. 10, pS74-S76, 3p, 1 Chart, 1 Graph |
| Abstract: | Objective: The authors assessed the possible correlations between different components of stromal compartment in gastric carcinomas. Methods: Four serial sections of 75 tumor areas from 59 patients with gastric carcinoma (GC) were stained with Gömöri technique, Masson's trichrome, α smooth muscle actin (ASMA) and CD34 immunomarkers to assess fibrillary constituents (FC), stromal specific cells (SSCs) and tumor stroma vascular network density (VD). Images were acquired and measurements were done with dedicated image analysis software. Statistical correlations were assessed with Pearson correlation test. Findings: Tumor stroma percentage generally varied between 10% and 40% of the tumor area. FC generally dominated the stromal architecture. Newly formed reticular fibers (Re-F) usually dominated the fibrillary compartment. ASMA+ cells dominated the cellular compartment. The vascular compartment showed great variability in the density of intratumoral network. SSCs number highly correlated with the amount of FC and especially Re-F. Re-F influenced both Re-F/Mature collagen fibers (Cl-F) ratio and the amount of FC. Consequently, the total amount of tumor stroma (TTS) correlated with FC/SSCs ratio. VD was in close correlation with the amount of vascular specific cells (CD34+) an also with the TTS and the number of FC producing cells. [ABSTRACT FROM AUTHOR] |
| Subject Terms: | IMAGE analysis software, CARCINOMA, SMOOTH muscle, STROMAL cells |
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| ISSN: | 22295089 |
| Database: | Complementary Index |
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