Academic Journal
Kluyveromyces marxianus: a potential biocatalyst of renewable chemicals and lignocellulosic ethanol production.
| Title: | Kluyveromyces marxianus: a potential biocatalyst of renewable chemicals and lignocellulosic ethanol production. |
|---|---|
| Authors: | Leonel, L. V., Arruda, P. V., Chandel, A. K., Felipe, M. G. A., Sene, L. |
| Source: | Critical Reviews in Biotechnology; Dec 2021, Vol. 41 Issue 8, p1131-1152, 22p |
| Abstract: | Kluyveromyces marxianus is an ascomycetous yeast which has shown promising results in cellulosic ethanol and renewable chemicals production. It can survive on a variety of carbon sources under industrially favorable conditions due to its fast growth rate, thermotolerance, and acid tolerance. K. marxianus, is generally regarded as a safe (GRAS) microorganism, is widely recognized as a powerhouse for the production of heterologous proteins and is accepted by the US Food and Drug Administration (USFDA) for its pharmaceutical and food applications. Since lignocellulosic hydrolysates are comprised of diverse monomeric sugars, oligosaccharides and potential metabolism inhibiting compounds, this microorganism can play a pivotal role as it can grow on lignocellulosic hydrolysates coping with vegetal cell wall derived inhibitors. Furthermore, advancements in synthetic biology, for example CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats with Cas9)-mediated genome editing, will enable development of an engineered yeast for the production of biochemicals and biopharmaceuticals having a myriad of industrial applications. Genetic engineering companies such as Cargill, Ginkgo Bioworks, DuPont, Global Yeast, Genomatica, and several others are actively working to develop designer yeasts. Given the important traits and properties of K. marxianus, these companies may find it to be a suitable biocatalyst for renewable chemicals and fuel production on the large scale. This paper reviews the recent progress made with K. marxianus biotechnology for sustainable production of ethanol, and other products utilizing lignocellulosic sugars. [ABSTRACT FROM AUTHOR] |
| Subject Terms: | KLUYVEROMYCES marxianus, LIGNOCELLULOSE, CELLULOSIC ethanol, ENZYMES, SYNTHETIC biology, GENOME editing |
| Company/Entity: | UNITED States. Food & Drug Administration, E.I. du Pont de Nemours & Co. |
| Copyright of Critical Reviews in Biotechnology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| ISSN: | 07388551 |
| DOI: | 10.1080/07388551.2021.1917505 |
| Database: | Complementary Index |
Availability