Academic Journal
Abstract Supplement Abstracts from AIDS 2022 ‐ the 24th International AIDS Conference, 29 July – 2 August 2022, Montréal, Canada & Virtual.
| Title: | Abstract Supplement Abstracts from AIDS 2022 ‐ the 24th International AIDS Conference, 29 July – 2 August 2022, Montréal, Canada & Virtual. |
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| Source: | Journal of the International AIDS Society; Aug2022 Supplement S1, Vol. 25, p1-288, 288p, 3 Color Photographs, 1 Black and White Photograph, 12 Diagrams, 53 Charts, 73 Graphs, 3 Maps |
| Abstract: | The retinoid (10mM) increased viral reactivation mediated by IL-15 to a similar extent as HODHBt (100mM) but unlike HODHBt, specifically promoted cell death of latently infected cells compared to controls when combined with IL-15. This indicates that the retinoid is able to reactivate latent HIV through a mechanism mediated by IL-15 but not directly dependent on STAT5 phosphorylation. Among the clinically relevant latency reversing agents (LRA) under investigation, IL-15 or the IL-15 superagonist N-803 have been shown to reactivate latent HIV I ex vivo i and I in vivo i . [Extracted from the article] |
| Subject Terms: | AIDS, CONFERENCES & conventions, KAPOSI'S sarcoma-associated herpesvirus, VIRUS reactivation, ANTIRETROVIRAL agents |
| Geographic Terms: | MONTREAL (Quebec), CANADA |
| Copyright of Journal of the International AIDS Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| ISSN: | 17582652 |
| DOI: | 10.1002/jia2.25935 |
| Database: | Complementary Index |
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