Book
ZO Proteins and Tight Junction Assembly.
| Title: | ZO Proteins and Tight Junction Assembly. |
|---|---|
| Authors: | Gonzalez-Mariscal, Lorenza, Fanning, Alan S. |
| Source: | Tight Junctions; 2006, p64-75, 12p |
| Abstract: | Tight junctions are highly structured plasma membrane domains. They are composed of transmembrane proteins, such as occludin and claudin (see Chapters 2 and 3), that are organized into highly cross-linked linear arrays of particles restricted to an apical circumferential band known as the apical junctional complex (AJC). These transmembrane proteins form a selective barrier in the paracellular space that is in turn intimately associated with a large array of tight junction-specific cytoplasmic, cytoskeletal, and signaling molecules (for a recent review see ref. 1). The high degree of order in this structure, and its ability to undergo rapid structural and functional changes in response to environmental stimuli, has created a great deal of interest in the underlying structural and organizational determinants of this array. Thus, much attention has been focused on three homologous polypeptides that are members of a large family of membrane-associated scaffolding proteins: ZO-1, ZO-2 and ZO-3, otherwise known as the ZO proteins. The emerging evidence suggests that these proteins organize not only the unique structure of tight junctions, but may also have a role in the functional organization of adhesion and signaling complexes in diverse cell types. [ABSTRACT FROM AUTHOR] |
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| DOI: | 10.1007/0-387-36673-36 |
| Database: | Supplemental Index |
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