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TJ Proteins That Make Round Trips to the Nucleus.
| Title: | TJ Proteins That Make Round Trips to the Nucleus. |
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| Authors: | Gonzalez-Mariscal, Lorenza, Lopez-Bayghen, Esther, Jaramillo, Blanca Estela, Huerta, Miriam, Betanzos, Abigail |
| Source: | Tight Junctions; 2006, p76-100, 25p |
| Abstract: | The tight junction (TJ) located at the limit between the apical and basolateral plasma membranes, is a multiprotein complex integrated by both integral and cortical proteins. Through TJ epithelial cells establish a link with their neighbors that seals the paracellular pathway. Lately some TJ proteins like the MAGUK ZO-1 and ZO-2, MAGI 1c, as well as the unrelated proteins symplekin and ubinuclein, have been found to concentrate at the nucleus. In this chapter we describe such proteins and how their arrival to the nucleus is connected to the degree of cell-cell contact. We analyze the signals present in these TJ proteins that may be responsible for their movement from the membrane to the nucleus and vice-versa. We then detail, the interaction of these proteins to nuclear molecules involved in gene transcription, chromatin remodeling, RNA processing and polyadenylation. In recent times, cell biologists have begun to recognize the dual location of certain proteins within the same cells. Such proteins appear to work as general constituents of two distant and different structures: they work as submembranous components of intercellular junctions and are also located in karyoplasms, Cajal bodies, or spliceosomes even in cells devoid of cell-cell junctions. Such proteins have recently been referred as NACos, for proteins that can localize to the nucleus and adhesion complexes. This chapter will deal with TJ proteins that shuttle between the plasma membrane and the nucleus. In all the cases so far studied, the subcellular distribution of the TJ NACo proteins is sensitive to the degree of cell-cell contact. Thus in epithelia cultured in a sparse condition, TJ NACos concentrate at the nucleus, whereas in a confluent state, they accumulate at the TJ and only a negligible proportion is maintained at the nucleus. Such behavior suggests that these proteins that mediate intercellular adhesion, also transmit information to the cell interior about the environment, such as the lack of neighboring cells. This information is crucial for deter-mining epithelial behavior, especially for keeping the balance between proliferation and differentiation. [ABSTRACT FROM AUTHOR] |
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| DOI: | 10.1007/0-387-36673-37 |
| Database: | Supplemental Index |
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