Book
The Privacy of T Cell Memory to Viruses.
| Title: | The Privacy of T Cell Memory to Viruses. |
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| Authors: | Compans, R. W., Cooper, M. D., Honjo, T., Koprowski, H., Melchers, F., Oldstone, M. B. A., Olsnes, S., Svanborg, C., Vogt, P. K., Wagner, H., Pulendran, Bali, Ahmed, Rafi, Welsh, R. M., Kim, S. K., Cornberg, M., Clute, S. C., Selin, L. K., Naumov, Y. N. |
| Source: | From Innate Immunity to Immunological Memory; 2006, p117-153, 37p |
| Abstract: | T cell responses to viral infections can mediate either protective immunity or damaging immunopathology. Viral infections induce the proliferation of T cells spe cific for viral antigens and cause a loss in the number of T cells with other specificities. In immunologically naïve hosts, viruses will induce T cell responses that, dependent on the MHC, recognize a distinct hierarchy of virus-encoded T cell epitopes. This hierarchy can change if the host has previously encountered another pathogen that elicited amemory pool of T cells specific to a cross-reactive epitope. This heterologous immunity can deviate the normal immune response and result in either beneficial or harmful effects on the host. Each host has a unique T cell repertoire caused by the random DNA rearrangement that created it, so the specific T cells that create the epitope hierarchy differ between individuals. This "private specificity" seems of little signifi-cance in the T cell responseof a naïvehost toinfection, but it is of profoundimportance under conditions of heterologous immunity, where a small subset of a cross-reactive memory pool may expand and dominate a response. Examples are given of how the private specificities of immune responses under conditions of heterologous immunity influence the pathogenesis of murine and human viral infections. [ABSTRACT FROM AUTHOR] |
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| DOI: | 10.1007/3-540-32636-7_5 |
| Database: | Supplemental Index |
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