Academic Journal
Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up
| Title: | Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up |
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| Authors: | Christopher J. Centeno, Zachary Fausel, Ehren Dodson, Dustin R. Berger, Neven J. Steinmetz |
| Source: | BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-14 (2024) |
| Subject Terms: | Rotator cuff tears, Cell therapy, Bone marrow concentrate (BMC), Exercise therapy, Platelet-rich plasma (PRP), Musculoskeletal pain, Diseases of the musculoskeletal system, RC925-935 |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the musculoskeletal system |
| Description: | Abstract Background Surgical repair is recommended for the treatment of high-grade partial and full thickness rotator cuff tears, although evidence shows surgery is not necessarily superior to non-surgical therapy. The purpose of this study was to compare percutaneous orthobiologic treatment to a home exercise therapy program for supraspinatus tears. Methods In this randomized-controlled, crossover design, participants with a torn supraspinatus tendon received either ‘BMC treatment’, consisting of a combination of autologous bone marrow concentrate (BMC) and platelet products, or underwent a home exercise therapy program. After three months, patients randomized to exercise therapy could crossover to receive BMC treatment if not satisfied with shoulder progression. Patient-reported outcomes of Numeric Pain Scale (NPS), Disabilities of the Arm, Shoulder, and Hand, (DASH), and a modified Single Assessment Numeric Evaluation (SANE) were collected at 1, 3, 6, 12, and 24 months. Pre- and post-treatment MRI were assessed using the Snyder Classification system. Results Fifty-one patients were enrolled and randomized to the BMC treatment group (n = 34) or the exercise therapy group (n = 17). Significantly greater improvement in median ΔDASH, ΔNPS, and SANE scores were reported by the BMC treatment group compared to the exercise therapy group (-11.7 vs -3.8, P = 0.01; -2.0 vs 0.5, P = 0.004; and 50.0 vs 0.0, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1471-2474 |
| Relation: | https://doaj.org/toc/1471-2474 |
| DOI: | 10.1186/s12891-024-07519-6 |
| Access URL: | https://doaj.org/article/d64d2169b9c5473f928a36fc832cf674 |
| Accession Number: | edsdoj.64d2169b9c5473f928a36fc832cf674 |
| ISSN: | 14712474 |
| DOI: | 10.1186/s12891-024-07519-6 |
| Database: | Directory of Open Access Journals |