Academic Journal
Mechanistic insights into the anti-restenotic effects of HSP27 and HO1 modulated by reconstituted HDL on neointimal hyperplasia
| Title: | Mechanistic insights into the anti-restenotic effects of HSP27 and HO1 modulated by reconstituted HDL on neointimal hyperplasia |
|---|---|
| Authors: | Ye Ji Kim, Zinah Hilal Khaleel, Myeongji Jin, Jo Woon Yi Lee, Seongchan Park, Seongmin Ga, Nam Hyeong Kim, Deok Hyang Sa, Eun Sung Kang, Seul Hee Han, Ji Yeun Lee, Hyo Jung Ku, Sang-Wook Kim, Ki Yong Kim, Jeong Euy Park, Yong Ho Kim, Bok-Soo Lee |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023) |
| Subject Terms: | Medicine, Science |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Description: | Abstract High-density lipoprotein (HDL) therapy has demonstrated beneficial effects in acute stroke and acute myocardial infarction models by reducing infarct size. In this study, we investigated the inhibitory effects of reconstituted HDL (rHDL) on neointimal hyperplasia and elucidated its underlying mechanism using a balloon injury rat model. Our finding revealed a significant 37% reduction in the intima to media ratio in the arteries treated with 80 mg/kg rHDL compared to those subjected to injury alone (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-49367-9 |
| Access URL: | https://doaj.org/article/6fb0e83fab8845be809ea143587e0f00 |
| Accession Number: | edsdoj.6fb0e83fab8845be809ea143587e0f00 |
| ISSN: | 20452322 |
| DOI: | 10.1038/s41598-023-49367-9 |
| Database: | Directory of Open Access Journals |