The Adam family of proteases / edited by Nigel M. Hooper and Uwe Lendeckel.
"The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through ad...
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| Other Authors: | , |
| Format: | Ebook |
| Language: | English |
| Published: |
Dordrecht :
Springer,
c2005.
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| Series: | Proteases in biology and disease
v. 4. |
| Subjects: | |
| Online Access: | Springer eBooks |
| Summary: | "The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis."--Publisher's website. |
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| Item Description: | Description based on print version record. |
| Physical Description: | 1 electronic document. |
| Format: | Mode of access: World Wide Web. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 0387251510 1280618671 9780387251516 9781280618673 |