Development and engineering of dopamine neurons / edited by R. Jeroen Pasterkamp, Marten P. Smidt, J. Peter H. Burbach.
"Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that...
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| Other Authors: | , , |
| Format: | Ebook |
| Language: | English |
| Published: |
New York, N.Y. : Austin, Tex. :
Springer Science+Business Media ; Landes Bioscience,
c2009.
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| Series: | Advances in experimental medicine and biology ;
v. 651. |
| Subjects: | |
| Online Access: | Springer eBooks |
| Summary: | "Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (md DA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the md DA system has been marked by the cloning and characterization of Nurrl and Pitx3. These transcription factors were shown to have a critical function during md DA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the md DA neuronal pool."--Publisher's website. |
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| Item Description: | Description based on print version record. |
| Physical Description: | 1 electronic document. |
| Format: | Mode of access: World Wide Web. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 1282824732 1441903224 9781282824737 9781441903228 |