Genomic imprinting / edited by Jon F. Wilkins.
"Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles....
Saved in:
| Corporate Author: | |
|---|---|
| Other Authors: | |
| Format: | Ebook |
| Language: | English |
| Published: |
New York, N.Y. : Austin, Tex. :
Springer Science+Business Media ; Landes Bioscience,
c2008.
|
| Series: | Advances in experimental medicine and biology ;
v. 626. |
| Subjects: | |
| Online Access: | Springer eBooks |
| Summary: | "Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles. These epigenetic differences include DNA methylation at Cp G dinucleotides, as well as modifications on the histones associated with the locus. In the simplest possible cases, the promoter region of the imprinted gene is methylated during oogenesis, but not spermatogenesis (or vice versa). This methylation (and its accompanying histone modifications) results in inactivation of the modified allele. Of course, most imprinted genes do not fall into this simplest case. The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field (which would necessarily span multiple books). Rather, the book covers on some of the more recent advances, with the goal of drawing attention to some of the emerging subtleties and complexities associated with imprinted genes."--Publisher's website. |
|---|---|
| Item Description: | Description based on print version record. |
| Physical Description: | 1 electronic document. |
| Format: | Mode of access: World Wide Web. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 0387775765 9780387775760 |