Androgen-responsive genes in prostate cancer : regulation, function and clinical applications / edited by Zhou Wang.
Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies. Understanding the functions of androgen-responsive genes and their regulation and deregula...
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| Format: | Ebook |
| Language: | English |
| Published: |
New York ; London :
Springer,
2013.
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| Online Access: | Springer eBooks |
| Summary: | Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies. Understanding the functions of androgen-responsive genes and their regulation and deregulation in prostate cancer progression may lead to new approaches to prevent and treat prostate cancer patients. This book provides an up-to-date review of the overall androgen-responsive gene expression program and the regulation, function, and clinical relevance of both protein coding and non-coding androgen-responsive genes. Experts in the field of androgen action and prostate cancer research discussed the importance of DNA elements, chromatin structure, cellular signaling, and cell-cell interactions in the regulation of androgen-responsive genes in the context of prostate cancer progression, including the development of CRPC. This book is intended for individuals interested in cancer endocrinology and medical and healthcare professionals involved in prostate cancer research. |
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| Physical Description: | 1 online resource |
| Format: | Mode of access: World Wide Web. |
| ISBN: | 1299337988 1461461820 9781299337985 9781461461821 |